ARS Writer Expands On New Tests For Botulism

 We wrote in May about the new, faster tests that are in the works for detecting botulism.  Sandy Miller Hays of the Agricultural Research Service picks up this subject in today's Everybody's Science. She writes:

Although cases of foodborne botulism are rare in the United States these days, they do still occur. Botulinum toxin occurs in seven different forms, known as serotypes A through G, although serotypes A and B are the culprits in about 90 percent of the foodborne botulism cases in the United States. (Botulism is the reason why your mother warned you to never, ever eat food from a can that’s dented, swollen or–heaven forbid–leaking.)

Botulinum is a protein that acts like a neurotoxin, interfering with the neurological system that otherwise transmits vital signals throughout your body. In particular, it can cut off normal messaging to muscles, causing paralysis. Worst-case scenario: The toxin paralyzes the muscles of your diaphragm and you die of suffocation.

Unfortunately, there is no federally approved vaccine against botulinum. An injection of horse antiserum can help remove the toxin from your bloodstream, but that treatment can cause serious side effects.

Its worth going to her site and reading the rest.

Carmel Restaurant Also In Canning Business Issues Recall Over Botulism

The Sea Harvest Restaurant of Carmel, CA is not a licensed cannery, but is recalling its canned cioppino sauce because there is a possibility it is contaminated with botulism.

The sauce was being canned by the Sea Harvest and sold as a retail product in the restaurant.

No illnesses have yet been associated with the recall.

The restaurant is cooperating with the California Department of Public Health and the Monterey County Health Department in the voluntary recall.

California officials said  Sea Harvest does not have the required cannery license to produce the cioppino sauce. 

MMWR Says Botulism Was Responsible For One of 11 Outbreak Deaths In 2006

We are very fortunate that while botulism is deadly it is also rare.

Today’s issue of Morbidity & Mortality Weekly Report (MMWR) published by the Centers for Disease Control & Prevention (CDC) carries an article that dissects all the food-borne disease outbreaks that occurred in 2006.

In “Surveillance for Foodborne Disease Outbreaks --- United States, 2006;” CDC looks at all 1,270 Food-borne Disease Outbreak (FBDOs) that were reported during that year, resulting in 27,634 confirmed illnesses and 11 deaths.

Only one of the 11 deaths was from Clostridium botulinum or botulism. That fatality was attributed to the C. botulinum toxin being transmitted by carrot juice.

Writing on his personal blog last December, Seattle food safety attorney Bill Marler told us what happened:

"For those that do not recall, in September 2006, three people living in Georgia developed food-borne botulism that was eventually traced to commercial carrot juice from a single bottle. Soon thereafter an additional case in Florida and two in Ontario, Canada surfaced. One of the 6 botulism patients died 90 days after illness onset. One year later, two others were still on ventilators. The remaining three were taken off ventilator support after 54, 90, and 129 days. Two survivors were at home, two were in rehabilitation facilities, and one was still hospitalized. All the patients had consumed carrot juice from the same manufacturer.

"Now, here is the interesting part, according to Dr. Anandi N. Sheth at the Centers for Disease Control in Atlanta, Georgia and colleagues, an investigation eventually determined that inadequate refrigeration probably led to botulinum toxin production. As the investigators pointed out, the pasteurized carrot juice had no protection against the bacterium Clostridium botulinum other than refrigeration. "This investigation demonstrates that carrot juice and other processed foods with no natural barriers to C. botulinum germination require additional chemical or thermal barriers," the investigators wrote in the medical journal Clinical Infectious Diseases. Accordingly, they report, "In June 2007, the FDA modified its guidance for refrigerated low-acid juices to recommend adding a validated juice-treatment method, such as acidification or appropriate thermal treatment, to decrease the risk of C. botulinum contamination, should any breaches in refrigeration occur."

Its comforting to know FDA may have addressed the problem and implemented the fix for the 2006 carrot juice outbreak.  However, it also shows that botulism from food products remains a concern.

 

Botulism Is Cause of Death For A Dozen Horses In Wyoming

The deaths in April of a dozen horses on one pasture in Natrona County, WY were due to botulism. Over last weekend, KCWY-13, Wyoming's NBC affiliate reported that:

Dr. George Marble says 3 horses were already dead on April 10th and when he went to the ranch he found two more that weren't able to walk. Within two days, all twelve the of the rancher's horses were dead or euthanized. Almost all the horses suffered paralysis of the legs and tongue which are both classic signs of botulism. The vet says no other pastures were affected by the toxin.

The veterinarian told KCWY-13, "the animals that were upstream so to speak from this particular pasture cause there was a little creek that ran through and those downstream from those horses and those that bordered on a fence line are all unaffected."

An equine health site associated with Horse Magazine says: "Horses usually become infected with botulism by ingesting the neurotoxin produced by the anaerobic bacterium Clostridium botulinum in contaminated feed or water. Feed contamination can occur when the decomposing carcass of a rodent or bird is baled in hay. This is seen more often in round bales. Feed can also be contaminated through improper storage or poor fermentation. Rarely, horses can get botulism when C. botulinum from the soil gets into an open wound."

KCWY-13 said it is extremely important for ranchers to check the hay before feeding, especially in the summer.

Here's A Picture Of "Fort Botulism!"

 “You know, it’s funny,” Vice President Joe Biden said. “Madame Speaker probably doesn’t want this publicized, but she has a secret BOTOX room inside the base of the Golden Gate Bridge. This way, in the event of a catastrophic shortage, she can still look like a 25-year old in an 85-year old’s body.” 

The Veep also said the facility keeping Speaker Nancy Pelosi's stock of botox was given a nick-name by Congress: Fort Botulism.

We know a lot of stuff on the internet isn't true, but wanted you to know how the name "Fort Botulism" became associated with the Golden Gate Bridge. It is true, however, that the Vice President today spoke to 1,046 graduating cadets at the United States Air Force Academy.

 

 

 

New, Faster Tests Being Developed For Detecting Deadly Botulism Toxin

 The rare, but deadly botulinum toxin is millions of times more poisonous than cyanide.  As dangerous as it is, the test for detecting botulinum toxin--an assay requiring the participation of laboratory mice, is neither quick nor easy. It takes from four to eight days, is not portable, nor very affordable.

A new, improved test for detecting what's known as "serotype A" of the toxin has now been developed by Agricultural Research Service (ARS) biologist Larry H. Stanker and colleagues at the ARS Western Regional Research Center in Albany, Calif.

The new test relies on laboratory built molecules known as monoclonal antibodies, which can bind to the toxin. Assisting the work are biologist Luisa W. Cheng and research associate Miles C. Scotcher.

The botulinum toxin that causes botulism occurs in seven different serotypes--A through G. A and B are culprits in most of the foodborne botulism cases in this country, according to Stanker.  The research team now expects to complete assays for detecting serotypes B and E sometime this year.

Safeguard Biosystems, Inc., of San Diego, CA., is packaging two of the serotype A antibodies into a dipstick-style test kit that looks and operates much like a home pregnancy test. The botulinum kit is intended for testing liquids, such as beverages, or clinical specimens, such as blood or urine.

That should be much quicker than waiting around for those lab mice.

ARS, a unit of the United States Department of Agriculture (USDA), has much more about this in its May/June magazine here.

Government Of Canada Warns Those Doing Home Canning And Fish Bottling To Take Steps To Avoid Deadly Botulism

 Health Canada and the Canadian Food Inspection Agency reminded Canadians of the importance of food safety while home canning or home bottling fish and other seafood. And they left no doubt about to whom their message was directed. The government said:

"Home canning and bottling of fish and other seafood is a popular activity for Canadians, especially in Atlantic Canada. However, improper preparation, canning or storage of these foods can cause serious illness, such as botulism."

Ottawa went on with this advice:

If you are home canning or bottling your own low-acid foods (including clams, lobster and whelks), the following steps will help to reduce the risk of contamination or the presence of C. botulinum:

- Use a pressure canner and strictly follow the manufacturer's instructions for canning or bottling foods considered to be low-acid, such as fish and other shellfish.

- Clean and sanitize your hands, all work surfaces, food, utensils, and equipment and keep them clean during all stages of the canning process.

- Do not substitute ingredients, amounts or the jar size that is in the recipe because this can cause the time or pressure needed during pressure canning to change. This can lead to bacteria remaining in the food. Use the final product within one year.

- Once the container has been opened, refrigerate leftovers immediately.

- If you are buying home canned products, ask the vendor if they have followed proper safety steps.

Always remember, never eat canned foods if you suspect the item has been tampered with, if the closure/seal has been broken, or if the container is swollen or leaking. If in doubt, throw it out!

The entire statement designed to prevent botulism can be found here.

 

USDA Advises Consumers Who Do Home Canning To Have Their Gauges Tested

The United States Department of Agriculture (USDA) recommends that pressure canner dial gauges be tested annually to be sure they are functioning properly.

Consumers who do home canning are advised to check with their state or county Extension Service to see if where tests can be conducted. Some local Extension Services offer the tests for free.

Pressure canners must be used to home can any low acid food including meats and poultry, vegetables and seafood.

You are in danger of botulism poisoning if using a pressure canner with a dial gauge that’s not reading accurately.

Only the pressure canner lid and dial gauge needs to be tested. 

CDC's Report On Tbe Botulism Outbreak That Brought Down Castleberry's

 

On July 7, 2007, the Centers for Disease Control and Prevention (“CDC”) learned that two siblings in Texas were critically ill with botulism and that their illnesses were likely acquired by eating contaminated food. Four days later on July 11, public health officials in Indiana reported to the CDC that a married couple in Indiana were suspected of having foodborne botulism. On July 17, CDC staff provided information regarding the production-dates and times to the FDA. The evidence strongly suggested that brands of Castleberry’s hot dog chili sauce were the common source of the four ill persons with botulism. By August 24, eight cases of botulism had been reported to the CDC. In addition to the Indiana couple, the mother of the children in Texas had developed symptoms of botulism, which brought the total number of Castleberry-associated cases in Texas to three. There were also three unrelated residents of Ohio who had developed botulism consuming Castleberry’s hot dog chili sauce in the week before symptom onsets. Botulinum toxin was identified in leftover chili sauce collected from the refrigerator belonging to one of the Ohio cases.

On July 18 and 19, a team of federal investigators were sent to the firm’s warehouse. Samples of Castleberry’s Austex and Castleberry’s brand Hot Dog Chili Sauce with the “best by May 7, 2009” and “best by May 8, 2009” lot codes were collected and sent to FDA laboratories for testing. FDA testing of sample 428113, consisting of 17 swollen cans, found C. Botulinum toxin in 16 of the cans. This sample included the same time-stamp and lot code from the May 8, 2007 production as the can found in the Indiana home. FDA testing of sample 420352, consisting of six swollen cans, found C. Botulinum in four cans. FDA sample 420353 included one swollen can, and its contents tested positive for C. Botulinum toxin.

Federal investigators conducted extensive tests on Castleberry equipment. The findings are presented in an FDA report issued on August 10, 2007.   Report below (click to download):

Malo Inc. and Massmann Enterprises designed and manufactured the sterilization equipment at the Castleberry's plant that made chili that was poisoned with botulism

Now after everything else went on -- the suffering of the victims of botulism, the recall, the permanent closure of the facility--Bumble Bee Foods is suing Malo and Massmann saying the equipment provided at the plant was negligent in design and maintenance.

Bumble Bee ran the Castleberry's plant when botulism toxin was found in its canned food products. They've filed a federal lawsuit in Augusta.

Bumble Bee managed Castleberry's 15th Street plant for the Connors Bros. Income Fund. It sold the rights to make Castleberry's products to another company, which closed the Augusta plant in November.

The 82-year old food processing plant closed permanently last November, putting 325 people out of work. That followed a $38 million recall that closed the plant for two months in the summer of 2007 when the Centers for Disease Control (CDC) blamed it for making people in three states sick with botulism.

The U.S. Food and Drug Administration (FDA) said the botulism toxin resulted from poor maintenance on two cookers and inadequate management oversight.